Bactrim for uti suppression and rifampin for therapy. (Photo: U.S. Food and Cytotec 100mcg $242.94 - $2.02 Per pill Drug Administration via Getty Images) Pfizer's decision to pull a popular antibiotic from the market this month reflects a much wider pattern affecting antibiotics and their use. It is a trend that increasingly reflected in the headlines. Last September, for example, The NewYork Times Magazine reported that an outbreak linked to overuse of antibiotics on farm animals had left one of America's biggest meat companies, Tyson Foods, scrambling to find new suppliers. The magazine's story was headlined, "Is Antibiotics the New Washing Machine?" Centers for Disease Control and Prevention has been urging the public for past several years to take note of this trend and, for good reason: In August 2007, it concluded that antibiotic-resistant infections cause more harm than good. In fact, there has been a shift in the way scientists view risks and benefits of antibiotic use, which has emerged over the past five years. In 2004, the Center on Global Drug Policy, of the University Minnesota and Global Anti-Antibiotic Resistance Institute, of New York University, issued Where to buy viagra online in usa a report in which they made the case that by not using antibiotics to treat humans and livestock, we are doing ourselves harm. The report was endorsed in March 2005 by the White House Council on Bioethics. The issued what they called a "Biological Weapon Resolution" – essentially, that in the case of a biological threat, we should act accordingly. But the report itself acknowledged that antibiotics kill people – not just those in hospitals or nursing homes – who become infections themselves. Even when not given to humans, antibiotics are used in agriculture to prevent diseases by killing disease-causing bacteria. And those bacteria will eventually develop resistant genes. More than a century of antibiotic stewardship The first prescription for antibiotics human use was a treatment to help people who were dying of the disease cholera as early 1818 (see "A Short History of Antibiotics"). The second was for ulcers caused by syphilis back in 1885. The third, of course, has been to treat humans whenever a bacterial infection has arisen. Over those centuries, antibiotics have been used extensively by medicine to help the sick and keep infections under control. For example, in 1917, scientists at Harvard Medical School began isolating bacteria that could fight infection. This led to the antibiotic penicillin, which was discovered by German-born French chemist Louis Pasteur in 1928. The first use of antibiotics for a wide variety of medical purposes was in the 1940s through efforts of scientists, doctors, and public-health officials. But scientists and health officials agree that there are important limitations to the use of new antibiotics. risk is not zero. The World Health Organization estimates that antibiotic-resistant infections cause roughly one out of three new bacterial infections worldwide. If this epidemic were in other developed nations, the death toll would be closer to 100,000 people per year. There are over 3 billion people at risk, according to the WHO. While the number of people at risk from these infections is small compared to the number of people receiving treatments for bacterial infections, this concern underscores why it was so important to identify how reduce the risks of resistant bacteria and to help control them. This was part of the effort behind an International Workshop for Food Safety and Labeling in 2013 on antimicrobial resistance food and livestock products to make sure that antibiotics are being used to treat humans and animals in the right way. And even after all this time, the problem has not gone away. The WHO recently identified bacteria causing a recent outbreak of tuberculosis in Japan as having acquired resistance to a group of drugs – called β-lactams used during treatment to treat the disease. There are several other examples of similar strains resistant bacteria. As antibiotics become less effective, the risk of these infections is growing. We can expect fewer and people to have access treatment. As this threat has become more widespread, a handful of companies have stepped up to ensure a future for their drugs in the marketplace. past week alone, Pfizer Inc. announced it is suspending sales of Viread, a drug for bacterial infections, after discovering that a number of the drug's patients received a potentially serious side effect. And on December 10, Gilead announced a new $100 million initiative that will focus on antibiotic resistance. Pfizer was first to market on this effort. The company in 1990s had begun research that resulted in two drugs, Trovan and Suboxone, which are also in some people's treatment routines today. With a long history of working to reduce antibiotic usage, including a voluntary initiative to stop selling drugs for human disease, Pfizer is one company that can help make sure a broad array of antibiotics remains on the market. And while Gilead may have a slightly different agenda – the company has made some decisions to reduce the use of.

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